Alzheimer Disease – gut connection
We specifically address four challenges in view of establishing our concept as a future prevention and therapy of AD:
Targeting the gut microbiota with a specific delivery of probiotic cocktail into the gut. Optimizing such a probiotic cocktail remains a challenge but offers a promising minimal invasive preventive and therapeutic approach.
Biochemistry and immunohistological assays together with longitudinal brain imaging ensure pre-clinical quality read outs and additional controls for the probiotic efficacy.
We suggest a novel and complementary high through- bar-code reading concept offering a fast and low-cost instrumentation for profiling the microbiota as well as the probiotic-induced alterations.
Preparing a “go to business” concept providing an “AD-gut” therapy and prevention.